MAPT and dementia: In controls, CSF t-tau (β [SE] = 8.49 [2.55] pg/mL per year; P = .002) and p-tau (β [SE] = 1.36 [0.41] pg/mL per year; P = .001) levels increased over time, and levels also increased for those in the amyloid-positive cognitively unimpaired (t-tau: β [SE] = 17.24 [4.58] pg/mL per year; P < .001; p-tau: β [SE] = 3.10 [0.72] pg/mL per year; P < .001) and amyloid-positive MCI (t-tau: β [SE] = 30.80 [5.99] pg/mL per year; P < .001; p-tau: β [SE] = 4.40 [0.93] pg/mL per year; P < .001) groups, with t-tau increasing further in the dementia group (β [SE] = 24.97 [7.80] pg/mL per year; P = .002).