However, the majority of antiviral ISGs, including OAS1, MX2, IFI6, IFITM1, IFI27, and IFTM2, were downregulated in cells transduced with MyD88 (in the presence or absence of infection) and were also downregulated in cells infected with UL88-deficient HCMV vs wild-type HCMV. Here, MYD88 is linked to infection.