The assessment of CD8+ T cell responses to Pf in humans is hampered by the relative weakness and fast decline of CD8+ responses in circulation after vaccination and their tissue residency at the site of infection, i.e., the liver after natural or immunization-mediated exposure to sporozoites (Weiss and Jiang, 2012; Trimnell et al., 2009; Schofield et al., 1987; Hoffman et al., 1989). Here, CD8A is linked to infection.