CD4 and infection: We analyzed the ICs on CD4+ and CD8+ T cells at five longitudinal time points, revealing significantly lower frequencies of total ICs+ in CD4+ (0, 21, 49, and 133 days post-infection) and CD8+ T cells (0, 49, 84, and 133 days post-infection) in ECs across all phases (Fig. 2A and B; Fig. S1).