TP53BP1 and cancer: Moreover, not all DNA is always replicated during S-phase: unreplicated DNA is detected in many cancer cells in mitosis; DNA synthesis can proceed during mitosis (mitotic DNA synthesis, MiDAS); while under-replicated DNA can lead to the formation of ultrafine bridges in anaphase and formation of structures in G1 stage of the next cell cycle that are bound by 53BP1 protein (53BP1 bodies) [12–14].