While one meta-analysis using data from studies of East Asian populations found a significant association between rs3826656 and the risk of Alzheimer’s disease (odds ratio 1.39, 95% CI 1.09–1.76),20 another employing three Asian cohorts and one Caucasian found no such association (odds ratio 0.94, 95% CI 0.62–1.41).21 Additionally, two recent large-scale studies yielded inconsistent findings regarding the relationship between CD33 and Alzheimer’s disease. This evidence concerns the gene CD33 and early-onset autosomal dominant Alzheimer disease.