Previous studies have shown that RNA‐seq analysis of the left ventricle within 0–72 h post‐acute MI reveals significant enrichment of pyroptosis pathways in 24‐h and 72‐h AMI samples compared to sham samples, alongside elevated levels of Caspase1 and GSDMD protein as AMI progresses [31, 32]. This evidence concerns the gene GSDMD and myocardial infarction.