RIPK3 and brain ischemia: The expression of necroptosis kinases, including MLKL/p-MLKL, RIPK3/p-RIPK3, and RIPK1/p-RIPK1, was significantly increased in the brain tissue of an OGD-induced neuronal injury model and the brain tissue of cerebral ischemia animal models (Fan et al., 2024; Yan et al., 2022).