RRM2 and hepatocellular carcinoma: In the GSE101728, GSE138178 and GSE146719 datasets, the expression of ALYREF, CDKN3, KIF3A, MCM10, and RRM2 was significantly increased in HCC samples compared to normal samples, whereas the expression of COLEC10, CPEB3, and PBLD was markedly decreased (p < 0.05; Fig. 5A–5C).