We identified DEmRNAs, DEmiRNAs, and DElncRNAs in HCC and found that high MCM10, CDKN3, RRM2, KIF3A, and ALYREF levels predict poor prognosis, while high CPEB2, COLEC10, and PBLD levels indicate better outcomes. The gene discussed is CDKN3; the disease is hepatocellular carcinoma.