AFP and neoplasm: All assessments of expansion of tumour burden and serum level of AFP show that exceeding Milan criteria is associated an increased prevalence of parameters linked to augmented risk of recurrence [[48], [49], [50]] (microscopic vascular invasion or satellites) with HRs ranging from 3.2 to 4.5 that were even higher than HR of 2.6 for being outside the MC [51] and thus impaired long-term outcome [[48], [49], [50]].