FASN and gestational diabetes: GDM significantly decreased hepatic de novo lipogenesis marker FAS (fatty acid synthase) protein at day 0 (P=0.024), day 6.5 (P<0.0001), and 17.5 (P=0.0001) compared to CD (Figure 2D) and there were main effects for GDM for ACC and phospho-ACC protein content (P<0.01, Figures 2E, F).