Four molecular subtypes were identified within ECs exhibiting the MELF pattern with the following distribution: 62.1% (95% CI: 55.7%-68.4%) CNL, 23.4% (95% CI: 17.9%-28.9%) MSI-H, 9.4% (95% CI: 3.9%-14.8%) CNH, and 3.4% (95% CI: 0%-6.8%) POLE-mutated. The gene discussed is POLE; the disease is Lafora disease.