SPI1 and neoplasm: Compared with the RPTS + oe-SPI1 + sh-NC group, tumor volume and weight in the RPTS + oe-SPI1 + sh-LCN2 group were reduced by 30.7% (from 715.16 ± 54.78 to 495.31 ± 75.21 mm3, 95.00% CI of diff 83.09 to 356.6) and 40.0% (from 0.40 ± 0.07 to 0.24 ± 0.05 g, 95.00% CI of diff 0.06722 to 0.2628), respectively (Figure 6F).