The results showed that ZNF433 exhibited significant diagnostic efficacy in several tumors, particularly in ACC, CESC, CHOL, GBM, GBMLGG, KICH, LAML, LGG, LIHC, PCPG, READ, SKCM, TGCT, THCA, and THYM. This evidence concerns the gene ZNF433 and glioblastoma.