The KRAB-ZFP family plays a critical role in cancer biology by regulating gene expression, cell cycle progression, and epigenetic modifications, thereby contributing to tumor initiation, progression, and therapeutic response (3, 67–70).Although several KRAB-ZFP family members have been identified as potential diagnostic biomarkers or therapeutic targets (12–15), the functional mechanisms of ZNF433—one of the less well-characterized members—remain poorly understood across various cancer types. The gene discussed is ZNF433; the disease is neoplasm.