CD274 and metastatic malignant neoplasm in the lymph nodes: Correlating the PD-L1 expression with the clinicopathological characteristics of the study cohort, we found that Lauren type, Epstein-Barr virus, microsatellite instability, lymph node metastasis, vascular metastasis,TNM stage, CD4+/CD8+ TILs and CD163+ TAMs were significantly associated with PD-L1 expression.