In univariate and multivariate analysis, Our data suggest that PD-L1 is significantly correlated with worse DFS and OS (both P< 0.05), and is likewise significantly associated with Lauren type, Epstein-Barr virus, microsatellite instability, lymph node metastasis, vascular metastasis and TNM stage, which is in line with the reported literature (46). Here, CD274 is linked to metastatic malignant neoplasm in the lymph nodes.