SMYD3 and cancer: Given the limited evidence regarding SMYD3’s role in the mechanisms regulating meiosis, numerous findings (Bernard et al., 2021) confirm its involvement in cell cycle regulation across various cellular models, including cancer, where its knockdown leads to reduced proliferation (Zhao et al., 2025; Ren et al., 2011; Asuthkar et al., 2022; Tsai et al., 2016; Sanese et al., 2024; Peserico et al., 2015).