F10 and Stroke: RoB 2.0: Risk of Bias 2.0; GIRAF: CoGnitive Impairment Related to Atrial Fibrillation; ENGAGE AF-TIMI 48: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48; ROCKET AF: Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation; RE-LY: Randomized Evaluation of Long-Term Anticoagulant Therapy