The Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) East Asian subgroup [13] showed that high-dose edoxaban significantly reduced both stroke risk (HR: 0.53; p = 0.02) and major bleeding (HR: 0.61; p = 0.011) compared to warfarin, while the low-dose regimen had the lowest bleeding rate (HR: 0.34; p < 0.001) with non-inferior efficacy. The gene discussed is F10; the disease is Stroke.