By analyzing the differences in the methylation status of these CpG sites between CRC tissues and adjacent normal tissues, we identified a hypermethylated CpG site in CRC tissues, namely, cg18258980, which is located in the open sea region (areas of the genome that are located more than 4 kb from CpG islands) of SATB2. Here, SATB2 is linked to colorectal carcinoma.