GADD45B and ischemic stroke: Our integration of multiple complementary machine-learning methods, like Boruta, SVM, LASSO, and random forest, provided rigorous confirmation of GADD45A, DUSP1, and GADD45B as robust biomarkers for ischemic stroke, substantially minimizing the risk of false discoveries inherent in genomic analyses (Zhou et al., 2023; Daneshvar and Mousa, 2023).