WS root extract constitutes withaferin A, withanolides, and withanosides, and at the molecular level, these compounds show beneficial effects in neurodegenerative diseases via inhibition of NF-κB activation, preservation of synaptic function, effect on cholinergic markers reduction, and improvement in antioxidant effects which is mediated by the migration of NRF2 to the nucleus, thereby resulting in the activation of antioxidant enzymes (Das et al., 2021). This evidence concerns the gene NFE2L2 and neurodegenerative disease.