The genes such as bradykinin receptor 1 (BDKRB1), NPY2R, PROKR2, SOX2 (sex determining region Y-box 2), Dickkopf-1 (DKK1), goosecoid homeobox (GSC), myeloid ecotropic insertion site 1 (MEIS1), and transcription factor AP-2β (TFAP2B) which were associated with unipolar depression, Alzheimer’s disease, sleep disturbances, and malignant glioma were downregulated in treated 100_3h vs. C_3h (Figure 4C). The gene discussed is SOX2; the disease is major depressive disorder.