Disease gene analysis revealed downregulation of HCRTR2, nitric oxide synthase 1 (NOS1), statherin (STATH), CSF2, fibroblast growth factor 14 (FGF14), retrotransposon-like protein 1 (RTL1), pancreatic polypeptide (PPY), and H4 clustered histone 3 (H4C3) genes which are responsible for migraine disorder, cognition and mild cognitive disorders, depressive symptoms, neuralgia, and peripheral neuropathy in 100_9h vs. 100_3h (Figure 4F). Here, H4C3 is linked to cognitive disorder.