Upregulated expression of antioxidant genes, viz., HMOX1, NFE2l2, SLC7A11, and NADPH oxidase, and downregulated expression of monooxygenase enzymes in our study could be a putative approach to deal with the oxidative stress in WS-treated human neuroblastoma SK-N-SH cells. This evidence concerns the gene HMOX1 and neuroblastoma.