Ccrk-deficient mice exhibit multiple abnormalities associated with ciliopathies and dysregulation of Hedgehog signaling, including neural tube patterning defects, polydactyly, and malformation of the lungs and eyes (Snouffer et al., 2017; Lupu et al., 2018; Lee and Ko, 2020). The gene discussed is CDK20; the disease is ciliopathy.