(6) Lack of data on additional clinical outcomes (e.g., GFR, albumin, and hemoglobin) in the included RCTs limited the depth of our analysis because these metrics are critical for assessing overall renal and nutritional status; (7) CRF encompasses a wide spectrum of CKD severity (stages 3–5), and treatment responses may vary across stages. The gene discussed is ALB; the disease is chronic kidney disease.