For example, the 2017 AAP guideline indicates that it would be reasonable to use aldosterone receptor antagonists (such as spironolactone) to treat resistant hypertension among children in a similar manner as in adults,45 and existing literature highlights the frequent combination of spironolactone with oral contraceptive pills to treat adolescent PCOS.27 The gene discussed is NR3C2; the disease is polycystic ovary syndrome.