EE was shown to increase the expression of LAMP-1 protein in animal models of chronic cerebral hypoperfusion (Page et al., 2021), vascular occlusion (Ismail et al., 2024), and stroke (Hooijmans et al., 2014) Additionally, EE led to a reduction in p62 protein levels under conditions of CUMS (Bailey et al., 2022), stroke (Xu et al., 2022), and chronic cerebral hypoperfusion (Page et al., 2021). The gene discussed is SQSTM1; the disease is Stroke.