LAMP1 and stroke disorder: EE was shown to increase the expression of LAMP-1 protein in animal models of chronic cerebral hypoperfusion (Page et al., 2021), vascular occlusion (Ismail et al., 2024), and stroke (Hooijmans et al., 2014) Additionally, EE led to a reduction in p62 protein levels under conditions of CUMS (Bailey et al., 2022), stroke (Xu et al., 2022), and chronic cerebral hypoperfusion (Page et al., 2021).