The generated long-term immunity could recognize and destroy cancer cells.44 Similarly, Luo et al indicated that decorating the surface of NPs using cancer cell membrane proteins and mannose to specifically target lymph nodes and DCs not only promotes robust antigen-specific CD8+ T-cell responses, but also elicits memory T-cells.45 It is worth noting that memory CD8+ T-cells are classified into two classes: (1) TCM which are localized in the lymph nodes and are CD3+ CD8+ CD62L+ CD44+ and (2) TEM which are found in non-lymphoid organs and are CD3+ CD8+ CD62L- CD44+. This evidence concerns the gene CD8A and cancer.