CD8A and neoplasm: This targeting system bypassed the need for the classical presentation and directly accessed the class I cytoplasmic MHC loading machinery, leading to a remarkable increase in DC stimulation of anti-tumor CD8+ T-cells.31 In another study, Meng et al designed a lipid-coated iron oxide NP to encapsulate peptide antigen and CpG DNA, as an adjuvant, and deliver them into cytosol and lysosomes of DCs.