The expression of leptin affects its ability to induce satiety and prevent obesity.17 In infants with HFD-induced obese mothers, elevated leptin hormone levels during breastfeeding induced rapid weight gain, according to a study by Lecoutre et al.18 Because it helps the offspring of obese dams reduce their food consumption, regulation of leptin and AMPK activity is important. The gene discussed is LEP; the disease is obesity disorder.