The expression of leptin affects its ability to induce satiety and prevent obesity.17 In infants with HFD-induced obese mothers, elevated leptin hormone levels during breastfeeding induced rapid weight gain, according to a study by Lecoutre et al.18 Because it helps the offspring of obese dams reduce their food consumption, regulation of leptin and AMPK activity is important. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.