FN1 and cancer: Fluegen et al showed that hypoxic ECM favours the shift of proliferative cancer cells to a quiescent state.28 Urokinase receptor interaction with alpha-5 beta-1 integrin stimulates cancer cell adhesion to fibronectin, stimulating ERK-mediated cell proliferation.29 Thus, increased adhesive features in senescent melanoma cells represent phenotypic reprogramming and essential features to maintain the quiescent state or balance between proliferative and cell arrest stimuli.