This phenomenon corresponded to our previous results that non-apoptotic BRAF-positive primary melanoma cells were characterized by enhanced migratory and invasive capacities after vemurafenib treatment.16 Recent data presumed that senescent cells have the potency to return to the proliferative state.37 Moreover, non-dividing cancer cells express various phenotypes, resulting in a heterogeneous population of slow-cycling cells16. The gene discussed is BRAF; the disease is cancer.