Fluegen et al showed that hypoxic ECM favours the shift of proliferative cancer cells to a quiescent state.28 Urokinase receptor interaction with alpha-5 beta-1 integrin stimulates cancer cell adhesion to fibronectin, stimulating ERK-mediated cell proliferation.29 Thus, increased adhesive features in senescent melanoma cells represent phenotypic reprogramming and essential features to maintain the quiescent state or balance between proliferative and cell arrest stimuli. Here, FN1 is linked to melanoma.