CASP3 and cancer: Our study resonates with these observations, indicating that the inhibition of autophagy sensitizes cancer cells to chemotherapeutic regimens, thereby intensifying apoptotic responses.34 Indeed, our data reveal that DOC potentiates the pro-apoptotic effects of ATO by upregulating Caspase 3 expression and downregulating BCL2, thereby shifting the cellular balance towards apoptosis-driven cell death.