SLC22A12 and hyperuricemia: Genetic variants in ABCG2, are crucial for understanding overall urate homeostasis, as genetic variants in this transporter can lead to decreased extrarenal urate excretion resulting in hyperuricemia.35 Genetic variations in genes encoding urate transporters, such as SLC2A9 (GLUT9), SLC22A12 (URAT1), and ABCG2, have been strongly linked to variations in serum urate levels and gout risk.