The onset of NASH revolves around fatty liver injury, and fatty degeneration, lobular inflammation, ballooning of hepatocytes, and fibrosis are considered its histological features.4,45 Due to the synergistic effect of FGF21 and GLP-1, this study primarily combined the GLP-1 target and FGF21 target on a dual action basis. This evidence concerns the gene GLP1R and metabolic dysfunction-associated steatohepatitis.