In a HDM-induced asthma model, IMs are the primary source of IL-10, and they significantly alleviate neutrophil-dominated airway inflammation by inhibiting the expression of Th2/Th17-related inflammatory cytokines such as IL-13, IL-17, GM-CSF, and TNF-α (Kawano et al., 2016). Here, CSF2 is linked to asthma.