TLR7 and asthma: In asthma patients infected with RV, IL-5 inhibits the function of pDCs and the expression of TLR7 by promoting the maturation and survival of eosinophils, thereby suppressing the antiviral response and leading to the exacerbation of asthma (Hatchwell et al., 2015; Dill-McFarland et al., 2022).