SIRT7 and infection: 1,588 upregulated and 897 downregulated DEGs were identified in SIRT7-KO cells compared to their expressions without GPS infection using the selection criteria: |log2Foldchange| ≥ 1 and P < 0.05 (Figure 4A, and Supplementary Table S1), While 543 genes were significantly upregulated, and 504 genes were significantly downregulated in SIRT7-KO cells compared to their expressions in WT cells infected with GPS (Figure 4B, and Supplementary Table S2).