In addition, we used the cytohubba plugin in Cytoscape software to identify the upregulated hub genes (ITGB1, ITGAV, ITGA6, THBS1, FN1, TGFB3, CCR1, FBN1, COL3A1, HSPA5) and the downregulated hub genes (NDUFS7, NDUFB7, BYSL, IMP4, EMG1, GRWD1, NOC4L, FBL, ATP5F1D, CYC1), which might coregulate GPS infection with SIRT7. Here, THBS1 is linked to infection.