While radiogenomic correlations have been well characterized in malignancies such as lung adenocarcinoma (16), hepatocellular carcinoma (17), head and neck squamous cell carcinoma (18), glioma (19), gastrointestinal tumor (20), and pancreatic cancer (21), no study has been reported in breast cancer regarding non-invasive biomarkers for STAT3 pathway activation and its clinical implications. The gene discussed is STAT3; the disease is breast cancer.