Specifically, RA patients exhibited markedly increased infiltration of plasma cells (p = 0.011) and follicular helper T (Tfh) cells (p = 0.033), while healthy controls showed higher levels of resting memory CD4+ T cells (p = 0.016), activated NK cells (p = 0.040), and activated mast cells (p = 0.004). This evidence concerns the gene CD4 and rheumatoid arthritis.