Numerous studies have suggested that CKAP2 promotes tumor cell proliferation, migration, and invasion through the JAK/STAT3 signaling pathway or the FAK-ERK2 pathway, which could contribute to poor disease prognosis (17, 35, 49, 50), as observed in cancers such as gastric adenocarcinoma, hepatocellular carcinoma, cervical carcinoma, and breast carcinoma (20, 22–24). This evidence concerns the gene CKAP2 and hepatocellular carcinoma.