This effect is mediated by the interaction between JAML and tumor-derived CXADR, which delivers co-stimulatory signals to activate naïve γδ T and CD8+ T cells while maintaining the activity of already activated cells (41).Further investigation into the regulation of JAML expression revealed, through a human chromatin interaction map, strong interactions between the JAML promoter and activation-induced intronic cis-regulatory regions near the CD3D promoter, indicating their role in controlling JAML expression. The gene discussed is CD8A; the disease is neoplasm.