SIRT1 and diabetic kidney disease: Furthermore, podocyte-specific deletion of Jaml significantly improved podocyte injury, reduced proteinuria, mitigated lipid accumulation, and restored kidney function in two DKD mouse models (streptozotocin-fed high-fat diet mice and db/db mice).Additional studies uncovered a novel function of JAML in regulating podocyte lipid metabolism through the Sirt1-mediated SREBP1 signaling pathway, where Sirt1 acts as a key mediator linking JAML to AMPK/SREBP1 signaling.