In this context, several conserved nuclear and nucleolar host factors required for virus infections in plants have been identified, such as importin α (Lukhovitskaya et al., 2015; Zhang et al., 2011), fibrillarin (Chang et al., 2016) and Exportin 1 (XPO1) (Zhang et al., 2021). The gene discussed is XPO1; the disease is viral infectious disease.