Relative to the HFD group, the HFD-L group exhibited 11 pathways associated with obesity: arginine and proline metabolism, ABC transporters, taurine and hypotaurine metabolism, metabolic pathways, glutathione metabolism, d-amino acid metabolism, histidine metabolism, protein digestion and absorption; and aminoacyl-tRNA biosynthesis. This evidence concerns the gene ABCG2 and obesity due to melanocortin 4 receptor deficiency.