SIRT3 and diabetes mellitus: This study demonstrated that: (1) Sirt3 mediates the cardioprotective effects of luteolin against post-resuscitation injury in diabetes; (2) Reduction of oxidative stress and inflammation via the Sirt3 signaling pathway contributes to preservation of mitochondrial function; and (3) Luteolin-activated Sirt3 signaling suppresses necroptosis, leading to improved cardiac outcomes after CA/CPR in diabetic rats.