Curcumin reduces MASLD by inhibiting NLRP3 and by modulating oxidative stress, lipid metabolism, AMPK and Nrf2 activation, gut microbiota, to control inflammation and lower hepatic steatosis; however, more research is needed to confirm their benefits in clinical MASLD patients [92]. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatotic liver disease.