ACTA2 and Hepatic fibrosis: Although TAA induced liver fibrosis in both miR-34b/c−/− and wild-type control mice (Figure 1A), livers of miR-34b/c−/− mice showed significantly increased collagen deposition, greater hydroxyproline content (Figures 1A–1C), and increased expression of fibrosis (Acta2, Ctgf, Tgfb1, and Timp1) and inflammatory marker (Ccl2 and Il6) genes compared to wild-type mice (Figures 1D and S1A).