Conversely, four immunophenotypes were associated with increased IPF risk: IgD− CD38dim %B cell (OR = 1.06, 95% CI = 1.01–1.06, p = 0.014), CD19 on CD20− (OR = 1.09, 95% CI = 1.00–1.18, p = 0.048), CD19 on IgD− CD27− (OR = 1.09, 95% CI = 1.00–1.19, p = 0.042), and CD25 on naive‐mature B cell (OR = 1.10, 95% CI = 1.01–1.19, p = 0.026). The gene discussed is CD19; the disease is idiopathic pulmonary fibrosis.