15 Similarly, a recent study implicated the disruption of lysosomal cholesterol homeostasis by the paracaspase MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) in glioblastoma suppression.16 It is worth noting that, unlike these previous studies, our research uniquely examined these effects in immunocompetent mice, explicitly assessing the immunostimulatory consequences of targeting lysosomal cholesterol transport. This evidence concerns the gene MALT1 and glioblastoma.