LEP and acute respiratory distress syndrome: As reviewed by Jutant and others, leptin plays a role in several lung diseases such as asthma, COPD, fibrosis, PH and lung cancer, but its role in acute onset of lung disorders, such as lung infections and acute respiratory distress syndrome (ARDS) remain controversial (Jutant et al. 2021; Malli et al. 2010) (Figure 1).