Placental alkaline phosphatase (PLAP) is a glycoprotein enzyme typically found in high levels in the placenta and EVs during pregnancy.[27, 28] While PLAP is primarily associated with normal placental tissue, elevated levels of PLAP have been observed in certain types of OC, particularly germ cell tumors and dysgerminomas.[29, 30, 31] While the exact role of PLAP in OC remains unclear, it is believed to contribute to tumor growth and progression. This evidence concerns the gene ALPP and testicular germ cell tumor.