LCN2 and ischemic stroke: 2021). Unlike GFAP, Lcn2 shows no expression in the healthy adult brain but increases a few 100‐fold in models of systemic neuroinflammation and ischemic stroke (Zamanian et al. 2012). Upregulation of Lcn2 in models of neuropathic pain, HIV‐related dementia, and Toxoplasma infection makes it particularly relevant for the study of reactive astrocytes in multiple disease and injury models (Ojeda‐Juárez et al. 2020; Agnew‐Svoboda et al. 2022).