TP53 and myelodysplastic syndrome: The outcomes indicated that age ≥ 60y (HR = 1.502, 95% CI 1.044–2.161, p = 0.028), ferritin > 1000 ng/ml (HR = 1.452, 95% CI 1.006–2.098, p = 0.047), poor chromosomal karyotype (HR = 1.865, 95% CI 1.019–3.413, p = 0.043), TP53 mutation (HR = 2.070, 95% CI 1.278–3.353, p = 0.003), and RUNX1 mutation (HR = 1.707, 95% CI 1.014–2.872, p = 0.044) are independent adverse prognostic factors for MDS patients.