Among them, TG (OR: 2.22, 95% CI: 1.45–3.37, PFDR = 0.035) and PXDN (OR: 1.33, 95% CI: 1.15–1.54, PFDR = 0.033) were associated with an increased risk of glaucoma, whereas CPXM1 (OR: 0.86, 95% CI: 0.81–0.91, PFDR < 0.001), FLT4 (OR: 0.74, 95% CI: 0.64–0.87, PFDR = 0.033), OMG (OR: 0.60, 95% CI: 0.47–0.77, PFDR = 0.029), INSR (OR: 0.58, 95% CI: 0.43–0.78, PFDR = 0.042), and CPZ (OR: 0.55, 95% CI: 0.40–0.74, PFDR = 0.033) were associated with a decreased risk of glaucoma. Here, INSR is linked to glaucoma.