Genetically predicted higher levels of CPXM1 [odds ratio (OR): 0.86, 95% confidence interval (CI): 0.81–0.91, PFDR < 0.001], FLT4 (OR: 0.74, 95% CI: 0.64 − 0.87, PFDR = 0.033), INSR (OR: 0.58, 95% CI: 0.43 − 0.78, PFDR = 0.042), and CPZ (OR: 0.55, 95% CI: 0.40 − 0.74, PFDR = 0.033) were associated with decreased glaucoma risk while those of PXDN (OR: 1.33, 95% CI: 1.15 − 1.54, PFDR = 0.033) with increased risk. This evidence concerns the gene CPZ and glaucoma.