TARDBP and frontotemporal dementia: Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is pathologically characterized by neuronal loss and gliosis in the frontal and temporal lobes as well as TDP-43 positive neuronal cytoplasmic inclusions (NCI), and variable dystrophic neurites (DN) and neuronal intranuclear inclusions [24].