TARDBP and supranuclear palsy, progressive, 1: Although the brain regions responsible for vertical gaze palsy are not fully understood, no significant neuronal loss or TDP-43 pathology was observed in the tegmentum or subthalamic nucleus—regions typically affected in PSP-RS and considered to be involved in oculomotor dysfunction [5, 14, 38]—in our FTLD-TDP-PSP cases.