CDCA2, Cell-division cycle associated 2, is involved in pathways which overlap across migraine with aura and without aura [25]; EBF2, Early B-cell factor 2, regulates dopaminergic neurons in the midbrain periaqueductal grey matter, which suggests pain modulatory impact [25]; and RPLP1, ribosomal protein lateral stalk subunit P1, involved in ribosome pathways of protein synthesis/degradation, has been shown to be related to MDD in a mouse model [20, 35]. The gene discussed is EBF2; the disease is migraine disorder.