DRD2 and migraine disorder: Conversely, synthetic ligands offer targeted interventions: antipsychotics such as risperidone and haloperidol antagonize DRD2, providing relief from psychotic symptoms in some cases, while dopamine agonists like bromocriptine and pramipexole hold promise in managing depressive symptoms or associated migraine features by stimulating DRD2 activity [138, 139].