Another class of drugs that has shown efficacy in preventing migraine and treating depression are the tricyclic antidepressants (TCAs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), which can potentiate the actions of serotonin and norepinephrine action by inhibiting reuptake via their respective transporters, the serotonin transporter (SERT) and the norepinephrine transporter (NET). The gene discussed is SLC6A2; the disease is migraine disorder.