The genotypes associated with these Fto SNPs affect the expression level of Fto (Berulava and Horsthemke, 2010; Pahl et al, 2023; Stratigopoulos et al, 2016; Zhang et al, 2023) and neighboring genes such as Rpgrip1l, Irx3, and Irx5, which are related to obesity (Smemo et al, 2014). Here, FTO is linked to obesity disorder.